10 Reasons to Consider the Organic Acids Test (OAT)
When it comes to solving chronic health puzzles, most patients have experienced the frustration of inconclusive blood work or one-size-fits-all treatment plans. Symptoms such as fatigue, brain fog, digestive issues, or mood changes often linger without clear answers. That’s where the Organic Acids Test (OAT) steps in—a functional medicine tool that provides an in-depth look at the body’s metabolic processes.
At Sunrise Functional Medicine, Dr. Kurt Woeller, D.O., uses the OAT test to uncover imbalances that often go undetected through standard lab work. With just a simple urine sample, patients gain valuable insight into how their body is functioning on a cellular level—opening the door to targeted treatments that can improve energy, mood, digestion, and overall well-being.
What is the Organic Acids Test?
Our bodies are powered by a constant stream of chemical reactions that produce tiny byproducts called organic acids. These compounds are excreted in urine, providing a “snapshot” of how efficiently our systems are working. If a chemical reaction is sluggish or blocked, certain organic acids build up in measurable amounts.
The OAT test captures these imbalances, offering clues into areas such as:
- Gut health and microbial balance
- Energy production within mitochondria
- Neurotransmitter activity (serotonin, dopamine, etc.)
- Nutrient deficiencies
- Detoxification capacity
Because the test only requires a first-morning urine collection, it’s easy to complete at home—even for children or individuals sensitive to blood draws. Results are analyzed using advanced technology (chromatography and mass spectrometry), providing detailed data on 76 organic acids.
Who Might Benefit from the OAT?
The OAT can be especially helpful for people with chronic or unexplained symptoms. Conditions commonly linked to imbalances revealed by this test include:
- Anxiety and depression
- Autism spectrum disorders
- Digestive complaints and gastrointestinal dysbiosis
- Chronic fatigue and fibromyalgia
- Diabetes and insulin resistance
- Neurological disorders
- Obesity and metabolic concerns
- Psychological or mood disorders
Even individuals who simply want to optimize their health can benefit. By identifying subtle nutrient deficiencies or early imbalances, the OAT supports a proactive approach to wellness.
10 Reasons the OAT Test is Valuable
Here are some of the most important ways the Organic Acids Test can shed light on chronic health concerns:
Detection of fungal toxins
The OAT identifies markers for candida and related fungal toxins—issues that stool tests often miss. Candida can disrupt brain function (mental fog, poor memory), cause digestive distress, and contribute to chemical sensitivities and muscle pain.
Evaluation of clostridia bacteria toxins
The test measures HPHPA and 4-cresol, two toxins linked to clostridia bacteria. These compounds interfere with dopamine metabolism, which may lead to mood swings, sleep disturbances, inflammation, and cognitive changes.
Guided treatment priorities
The OAT helps practitioners distinguish whether symptoms stem from candida, clostridia, or another imbalance. This prevents misdirected treatments that can worsen symptoms rather than resolve them.
Assessment of oxalates
Oxalates—naturally occurring compounds in many foods—can accumulate due to candida overgrowth. High levels contribute to joint pain, connective tissue problems, and even heavy metal retention (mercury, lead, arsenic).
Insight into mitochondrial health
Mitochondria are the “energy factories” of cells, and dysfunction here is linked to fatigue, adrenal exhaustion, and chronic illness. The OAT reveals if toxins or nutrient deficiencies are impairing energy production.
Neurotransmitter balance
The test evaluates dopamine (HVA) and norepinephrine (VMA), two brain chemicals essential for focus, calmness, and emotional stability. Imbalances here may explain attention issues, anxiety, or irritability.
Serotonin and brain stress markers
Beyond dopamine, the OAT also assesses serotonin pathways and markers of toxic stress such as quinolinic acid. Elevated levels can worsen neurological inflammation and must be addressed before introducing certain supplements.
Folate metabolism insights
The test measures key compounds related to folate and methylation—processes critical for DNA function, detoxification, and overall cellular health.
Nutritional marker evaluation
The OAT provides details on essential nutrients like B vitamins, vitamin C, CoQ10, and NAC (a precursor to glutathione). Deficiencies here may underlie fatigue, mood changes, or immune weakness.
Glutathione production capacity
Glutathione is the body’s master antioxidant, responsible for detoxification and cellular protection. Low glutathione is often seen in autism and chronic illness, and the OAT reveals whether production pathways are compromised.
More Than Just a Test: A Metabolic Roadmap
Unlike standard labs that may only flag disease when it’s advanced, the OAT shines light on early functional imbalances. By mapping out the interplay between gut health, energy production, neurotransmitters, and nutrient status, this test provides a roadmap for personalized healing. Dr. Woeller and Dr. Tracy Tranchitella offer more than just lab results—they provide personalized written interpretations with clear action steps. These recommendations may include supplement protocols, dietary strategies, detoxification support, or lifestyle changes. This patient-centered approach helps individuals move from frustration and trial-and-error to targeted solutions that restore balance.
Why Functional Medicine Relies on the OAT
Functional medicine emphasizes treating root causes rather than masking symptoms. Because the OAT reflects how the body’s systems are functioning in real time, it gives practitioners a unique window into the “why” behind a patient’s symptoms. For example, instead of simply prescribing medication for anxiety, the OAT might reveal a serotonin imbalance, B6 deficiency, or gut dysbiosis driving the mood issues. Addressing those root causes often leads to more sustainable improvements.
Taking the Next Step
If you’ve been struggling with unexplained health issues—or if you’re simply ready to take a proactive step toward optimal wellness—the Organic Acids Test may be an invaluable tool. Dr. Kurt Woeller has extensive experience using the OAT to guide treatment for children, adults, and individuals with complex chronic conditions. At Sunrise Functional Medicine, he integrates the insights from this test into personalized care plans that empower patients to heal from the inside out.
By uncovering hidden imbalances, the OAT provides answers where traditional lab work falls short. It’s not just a test—it’s a step toward clarity, empowerment, and better health.