GcMAF – An Emerging Therapy for Immune Disorders Seen In Autism, Other Neurodevelopmental Disorders, and Chronic Health Conditions

Dr. Kurt N. Woeller

Immune system problems are rampant these days. Cancer is on the rise, more and more people are suffering with ill-health, and debilitating disorders of the nervous system are often tied to problems with immune function. For individuals with autism who have documented immune imbalances there are various therapies that can help restore health and improve their overall brain function. GcMAF is one such therapy that is showing great promise and benefit.
GcMAF stands for vitamin D-binding protein derived macrophage activating factor. The Gc is the Gc-globlin (vitamin D binding protein). In a healthy individuals the GcMAF helps to command the immune system into action by directing cells called macrophages (macro = large, phage = to eat) which attack and engulf various pathogens. They are a type of white blood cell that becomes activated by inflammation and help to coordinate immunoglobulin production for further immune system reactivity. We need macrophages to function properly to neutralize various infectious agents and cancer cells.
Cancer cells and cells often infected with viruses can produce an enzyme called Nagalase. Nagalase neutralizes GcMAF and therefore macrophages do not get the signal to go into action. Overtime cancer cells go unchecked and chronic infections can persist. Chronic infections are quite common in autism.
GcMAF can now be isolated from healthy human serum and is available as an immune supportive therapy in the United States and abroad. GcMAF is given by an injection using a 0.3ml insulin syringe (small needle) once weekly. For cancer patients this therapy can last 8 to 18 months depending on the severity and stage of the disease. HIV and chronic fatigue patients may need therapy upwards of 6 to 8 months, and in autism treatment courses vary, but 4 to 8 months should be expected.

There are various blood tests that should be ascertained prior to GcMAF therapy. Most specifically is a Nagalase test available through Vitamin Diagnositics, as well as complete blood count with differential (CBC w/Diff) and vitamin D as 25(OH)D (which can be done from almost any hospital or clinic laboratory). I also recommend doing an initial comprehensive metabolic panel including liver and kidney function as well (although there are no known recorded cases of liver and/or kidney toxicity from GcMAF therapy).

Two excellent websites you need to visit to learn more about this therapy are – Immune Medicine.com and GcMAF.eu. The latter has more specific information about GcMAF for autism, how to obtain it, etc.

14 Responses to “GcMAF – An Emerging Therapy for Immune Disorders Seen In Autism, Other Neurodevelopmental Disorders, and Chronic Health Conditions”

  1. Mary Mollway
    03. Jul, 2012 at 7:55 pm #

    Dr. Woeller,

    What about using this treatment therapy for long-term illnesses such as Epstein Barr and Lyme? I was diagnosed with Epstein-Barr in January and my immune system is being overrun by this virus. As it is known to causes lymphoma, lupus, and MS,and I am eager to get it into check.

    • bwoeller
      05. Jul, 2012 at 4:45 pm #

      Most certainly. This therapy is helpful for chronic viral infections. I have not used it in Lyme, but this is a potential too. Brittany from the office could order the test for you if you would like.
      Dr. Woeller

    • Lesley
      10. Jul, 2012 at 7:51 am #

      Hi, as the statistician for gcmaf.eu, I can confirm that there are a number of people who take this for Lyme and EBV with good results. In addition it is used successfully in HIV, cancer, CFS and autism. The trouble is that this then gets accused of being a ‘magic bullet’ and a ‘con’ because it helps with so many problems. But you have to bear in mind that GcMAF doesnt cure anything. It is a necessary part of your immune system without which your immune system does not work effectively. It is a good immune system that deals with all of these problems (and a great deal more), but without GcMAF, your immune system is overwhelmed by infections.

  2. Maria Cabanillas Serrano
    05. Sep, 2012 at 10:57 am #


    Tengo un niño diagnosticado de TEA y me gustaria tener más información sobre todo este tratamiento, los efectos adversos etc

    Un saludo y muchas gracias

  3. Carol
    20. Oct, 2012 at 4:02 pm #

    Do you have any information on whether this therapy has been helpful with PANDAS?

    14. Jan, 2013 at 3:22 pm #

    Hello, my five year old brother is in the autistic spectrum we started a treatment with gcmaf its been four weeks now, ever since his behavior has changed a lot he is a lot more agresive which he wasnt at all and he has been biting alot which he never did as well…. we dont know if we should stop the treatment or continue.
    any help?

    • Philippe
      05. Apr, 2013 at 8:29 am #

      Hope you didn’t start and progressively increased the amount at each injection (0.01 or 0.02 ml more each time). You decrease if he reacts too strongly, but the strong reaction (agressive) just means that his immune system is reacting, beating the viruses that release more toxine to this agression as a response. So you beat them, and your children body will end winning the battle. Overreaction is very common and is a “good” sign.

    • gail
      06. Apr, 2013 at 9:04 pm #

      we started GcMaf I’ve heard to avoid negative reaction u need to go very slow. 0.01, then 0.02, 0.03 each week. Find reputable source and experience MAP doctor.
      Also to maximize effect adequate level vitamin D is necessary. Ashwaganda supplements can support effect.

  5. Ann
    21. Mar, 2013 at 5:57 am #

    I would ask the doctor you are working with. I know with Autism you should star with a low dose and then build up slowly. I think there are some websites that talk about proper dosages. If I were you I would lower the dose, or stop for a short time, see what happens, then start again with the small dose. There could be some die off issues going on. Also, it is probably best to have other issues resolved first such as food sensitivities, needed supplements and getting candida overgrowth under control. Best of luck. Don’t give up. There are a lot of great websites out there like mb-12 valtrex where lots of experts give advice on all kinds of treatments. Also, I always pray to know what to do. It helps.

  6. Judy
    29. Jun, 2013 at 9:27 am #

    Would this therapy be beneficial for Crohn’s disease?

  7. Rose Trupkovic
    30. Jul, 2013 at 11:11 am #

    Hi I am interested in learning how this treatment would benefit my sister who has progressive MS. She has had MS for 20 years and 12 years ago she battled bowel cancer, she is now 43 years of age. My question is does this treatment have severe side effects and will this be able to mend some of the damage MS has already caused.


  8. Any Specialist in Autesm
    21. Oct, 2013 at 9:44 am #

    Hi Please advice us were is the best place to use GcMaf treatment for Autesm,We have a child who is not capable of speaking he is almost 5 years old,he was diagnosed as having a certain degree of Autesm.
    Thank you and,Best regards
    Azzeddin Elhawej

  9. David
    04. Nov, 2013 at 9:56 pm #

    What type of injection subcutaneous?

  10. Shameer
    14. Nov, 2013 at 12:27 pm #

    My 7 years nephew is completely disabled physic by birth due to autism. Will this medicine help for any improvement?

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